Assay Detail
Binding
CHEMBL616337
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Binding affinity against 5-hydroxytryptamine 1A receptor in rat cerebral cortical membrane using [3H]-8-OH-DPAT as radioligand.
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155823 | — | — | 1 | 8.30 |
| CHEMBL345810 | — | — | 1 | 8.20 |
| CHEMBL156585 | — | — | 1 | 8.10 |
| CHEMBL160918 | — | — | 1 | 8.10 |
| CHEMBL345214 | — | — | 1 | 8.00 |
| CHEMBL1200399 | BUSPIRONE HYDROCHLORIDE | 4.0 | 1 | 7.90 |
| CHEMBL1203597 | — | — | 1 | 7.90 |
| CHEMBL1202288 | — | — | 1 | 7.80 |
| CHEMBL346122 | — | — | 1 | 7.80 |
| CHEMBL160607 | — | — | 1 | 7.70 |
| CHEMBL1203631 | — | — | 1 | 7.70 |
| CHEMBL1202289 | — | — | 1 | 7.60 |
| CHEMBL156229 | — | — | 1 | 7.60 |
| CHEMBL1203603 | — | — | 1 | 7.60 |
| CHEMBL1203625 | — | — | 1 | 7.60 |
| CHEMBL1202291 | — | — | 1 | 7.50 |
| CHEMBL1203624 | — | — | 1 | 7.50 |
| CHEMBL348058 | — | — | 1 | 7.50 |
| CHEMBL1203595 | — | — | 1 | 7.40 |
| CHEMBL1203623 | — | — | 1 | 7.30 |
| CHEMBL1203600 | — | — | 1 | 7.30 |
| CHEMBL1203598 | — | — | 1 | 7.30 |
| CHEMBL346276 | — | — | 1 | 7.30 |
| CHEMBL1203644 | — | — | 1 | 7.20 |
| CHEMBL348273 | — | — | 1 | 7.10 |
| CHEMBL158505 | — | — | 1 | 7.10 |
| CHEMBL123349 | — | — | 1 | 7.00 |
| CHEMBL1237145 | — | — | 1 | 7.00 |
| CHEMBL1202290 | — | — | 1 | 7.00 |
| CHEMBL160186 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155823 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL345810 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL160918 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL156585 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL345214 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1200399 | BUSPIRONE HYDROCHLORIDE | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1203597 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL346122 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1202288 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL160607 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1203631 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1202289 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1203625 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1203603 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL156229 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1202291 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL348058 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1203624 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1203595 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL346276 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1203600 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1203623 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1203598 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1203644 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL348273 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL158505 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL123349 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1237145 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1202290 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL160186 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL1203611 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL1203645 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL1203602 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL1203629 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1203601 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL1203596 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1203613 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL1203614 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL1202292 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL1203612 | — | Ki | = | 6309.57 | nM | 5.20 |