Assay Detail
Binding
CHEMBL616368
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Binding affinity against 5-hydroxytryptamine 1A receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT1A receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.40 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430332 | — | — | 1 | 10.00 |
| CHEMBL165718 | — | — | 1 | 9.05 |
| CHEMBL349003 | — | — | 1 | 8.72 |
| CHEMBL56183 | — | — | 1 | 8.41 |
| CHEMBL354668 | — | — | 1 | 7.13 |
| CHEMBL163884 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430332 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL165718 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL349003 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL56183 | — | Ki | = | 3.87 | nM | 8.41 |
| CHEMBL354668 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL163884 | — | Ki | = | 79.0 | nM | 7.10 |