Assay Detail
Binding
CHEMBL616370
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Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.52 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 9.40 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.40 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 7.62 |
| CHEMBL434665 | — | — | 1 | 7.24 |
| CHEMBL419792 | SUMANIROLE | 3.0 | 1 | 7.14 |
| CHEMBL422344 | — | — | 1 | 7.04 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 5.77 |
| CHEMBL348285 | — | — | 1 | - |
| CHEMBL345458 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL531 | PERGOLIDE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL434665 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL419792 | SUMANIROLE | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL422344 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL589 | ROPINIROLE | Ki | = | 1706.0 | nM | 5.77 |
| CHEMBL348285 | — | Ki | > | 3257.0 | nM | - |
| CHEMBL345458 | — | Ki | > | 3521.0 | nM | - |