Assay Detail
Functional
CHEMBL616669
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Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.20 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296161 | — | — | 1 | 9.40 |
| CHEMBL420965 | — | — | 1 | 9.10 |
| CHEMBL116092 | — | — | 1 | 8.64 |
| CHEMBL163462 | — | — | 1 | 8.42 |
| CHEMBL163376 | — | — | 1 | 7.96 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.85 |
| CHEMBL117249 | — | — | 1 | 7.27 |
| CHEMBL324931 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296161 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL420965 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL116092 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL163462 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL163376 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL117249 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL324931 | — | EC50 | = | 105.0 | nM | 6.98 |