Compound Detail
CHEMBL324931
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Basic Information
| ChEMBL ID | CHEMBL324931 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YOIQHSYPJYUDKZ-UHFFFAOYSA-N |
2
Targets
6
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
310.4
MW (Da)
1.54
ALogP
5
HBA
1
HBD
53.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.87
EC50 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1D CHEMBL1983 | EC50 | 7.1 | 7.04 | 80.0 | 2 |
| 5-hydroxytryptamine receptor 1D CHEMBL1983 | IC50 | 6.87 | 6.86 | 134.0 | 2 |
| 5-hydroxytryptamine receptor 1B CHEMBL1898 | IC50 | 6.52 | 6.515 | 304.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1D | EC50 | = | 80.0 | nM | 7.1 | Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytrypta... | 9357515 |
| 5-hydroxytryptamine receptor 1D | EC50 | = | 105.0 | nM | 6.98 | Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytr... | 10052976 |
| 5-hydroxytryptamine receptor 1D | IC50 | = | 134.0 | nM | 6.87 | Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D rece... | 10052976 |
| 5-hydroxytryptamine receptor 1D | IC50 | = | 140.0 | nM | 6.85 | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in... | 9357515 |
| 5-hydroxytryptamine receptor 1B | IC50 | = | 304.0 | nM | 6.52 | Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B recept... | 10052976 |
| 5-hydroxytryptamine receptor 1B | IC50 | = | 310.0 | nM | 6.51 | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in... | 9357515 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10052976 | 10.1021/jm980569z | 5-hydroxytryptamine receptor 1D | 3 |
| 9357515 | 10.1021/jm9704560 | 5-hydroxytryptamine receptor 1D | 3 |
| 10052976 | 10.1021/jm980569z | 5-hydroxytryptamine receptor 1B | 1 |
| 10052976 | 10.1021/jm980569z | Serotonin 1 receptors; 5-HT1B & 5-HT1D | 1 |
| 9357515 | 10.1021/jm9704560 | 5-hydroxytryptamine receptor 1B | 1 |
| 9357515 | 10.1021/jm9704560 | Serotonin 1 receptors; 5-HT1B & 5-HT1D | 1 |
Data from ChEMBL 36 via Core Engine