Assay Detail
Binding
CHEMBL616911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.74 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL161723 | — | — | 1 | 10.00 |
| CHEMBL65367 | — | — | 1 | 10.00 |
| CHEMBL161176 | — | — | 1 | 9.70 |
| CHEMBL163462 | — | — | 1 | 9.70 |
| CHEMBL422366 | — | — | 1 | 9.52 |
| CHEMBL163573 | — | — | 1 | 9.40 |
| CHEMBL162805 | — | — | 1 | 9.40 |
| CHEMBL292779 | — | — | 1 | 9.30 |
| CHEMBL161696 | — | — | 1 | 9.30 |
| CHEMBL116031 | — | — | 1 | 9.30 |
| CHEMBL159396 | — | — | 1 | 9.22 |
| CHEMBL162858 | — | — | 1 | 9.22 |
| CHEMBL163386 | — | — | 1 | 9.15 |
| CHEMBL347665 | — | — | 1 | 9.15 |
| CHEMBL352159 | — | — | 1 | 9.10 |
| CHEMBL162722 | — | — | 1 | 9.10 |
| CHEMBL115750 | — | — | 1 | 9.10 |
| CHEMBL348962 | — | — | 1 | 9.05 |
| CHEMBL119668 | — | — | 1 | 9.05 |
| CHEMBL351346 | — | — | 1 | 9.00 |
| CHEMBL164035 | — | — | 1 | 9.00 |
| CHEMBL119785 | — | — | 1 | 8.89 |
| CHEMBL117633 | — | — | 1 | 8.85 |
| CHEMBL162463 | — | — | 1 | 8.85 |
| CHEMBL164413 | — | — | 1 | 8.80 |
| CHEMBL163127 | — | — | 1 | 8.60 |
| CHEMBL352123 | — | — | 1 | 8.31 |
| CHEMBL351311 | — | — | 1 | 8.31 |
| CHEMBL161970 | — | — | 1 | 8.28 |
| CHEMBL162899 | — | — | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL161723 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL65367 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL163462 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL161176 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL422366 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL163573 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL162805 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL292779 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL161696 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL116031 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL162858 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL159396 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL163386 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL347665 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL115750 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL352159 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL162722 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL348962 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL119668 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL351346 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL164035 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL119785 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL117633 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL162463 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL164413 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL163127 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL352123 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL351311 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL161970 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL162899 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL163114 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL162930 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL331612 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL274001 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL117249 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL324931 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL161969 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL422191 | — | IC50 | = | 210.0 | nM | 6.68 |