Assay Detail
Binding
CHEMBL617032
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Binding affinity for 5-hydroxytryptamine 2 receptor of rat cortical membrane using [3H]DOB radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.33 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125745 | — | — | 1 | 8.32 |
| CHEMBL126340 | — | — | 1 | 8.18 |
| CHEMBL92139 | — | — | 1 | 7.75 |
| CHEMBL76237 | — | — | 1 | 7.19 |
| CHEMBL93868 | — | — | 1 | 7.08 |
| CHEMBL317535 | — | — | 1 | 6.89 |
| CHEMBL263700 | — | — | 1 | 6.70 |
| CHEMBL127411 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125745 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL126340 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL92139 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL76237 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL93868 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL317535 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL263700 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL127411 | — | Ki | = | 320.0 | nM | 6.50 |