Assay Detail
Binding
CHEMBL617107
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Ability to stimulate phosphoinositide hydrolysis in NIH3T3 cells expressing the 5-hydroxytryptamine 2A receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.20 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6706 | — | — | 1 | 8.57 |
| CHEMBL7132 | — | — | 1 | 8.42 |
| CHEMBL6710 | — | — | 1 | 8.08 |
| CHEMBL6907 | — | — | 1 | 7.92 |
| CHEMBL263083 | — | — | 1 | 7.72 |
| CHEMBL6452 | — | — | 1 | 7.55 |
| CHEMBL268542 | — | — | 1 | 7.52 |
| CHEMBL263078 | — | — | 1 | 7.46 |
| CHEMBL6620 | — | — | 1 | 7.17 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.14 |
| CHEMBL6871 | — | — | 1 | 6.23 |
| CHEMBL6838 | — | — | 1 | 6.19 |
| CHEMBL268587 | — | — | 1 | 5.63 |
| CHEMBL268072 | — | — | 1 | 5.25 |
| CHEMBL6737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6706 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL7132 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL6710 | — | EC50 | = | 8.38 | nM | 8.08 |
| CHEMBL6907 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL263083 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL6452 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL268542 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL263078 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL6620 | — | EC50 | = | 68.4 | nM | 7.17 |
| CHEMBL6607 | BROLAMFETAMINE | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL6871 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL6838 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL268587 | — | EC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL268072 | — | EC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL6737 | — | EC50 | > | 10000.0 | nM | - |