Assay Detail
Functional
CHEMBL617112
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In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.76 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134519 | — | — | 1 | 7.56 |
| CHEMBL133455 | — | — | 1 | 7.10 |
| CHEMBL133868 | — | — | 1 | 6.94 |
| CHEMBL131736 | — | — | 1 | 6.87 |
| CHEMBL27173 | — | — | 1 | 6.74 |
| CHEMBL275854 | — | — | 1 | 6.74 |
| CHEMBL25800 | — | — | 1 | 6.67 |
| CHEMBL31115 | — | — | 1 | 6.54 |
| CHEMBL135076 | — | — | 1 | 6.54 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.46 |
| CHEMBL412876 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134519 | — | EC50 | = | 27.7 | nM | 7.56 |
| CHEMBL133455 | — | EC50 | = | 80.1 | nM | 7.10 |
| CHEMBL133868 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL131736 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL27173 | — | EC50 | = | 181.0 | nM | 6.74 |
| CHEMBL275854 | — | EC50 | = | 184.0 | nM | 6.74 |
| CHEMBL25800 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL31115 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL135076 | — | EC50 | = | 292.0 | nM | 6.54 |
| CHEMBL39 | SEROTONIN | EC50 | = | 351.0 | nM | 6.46 |
| CHEMBL412876 | — | EC50 | = | 660.0 | nM | 6.18 |