Assay Detail
Binding
CHEMBL617114
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Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.56 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.01 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.14 |
| CHEMBL116940 | — | — | 1 | 6.92 |
| CHEMBL119323 | — | — | 1 | 5.96 |
| CHEMBL445106 | — | — | 1 | 5.68 |
| CHEMBL65547 | PSILOCIN | 2.0 | 1 | 5.64 |
| CHEMBL119584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL6607 | BROLAMFETAMINE | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL116940 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL119323 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL445106 | — | EC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL65547 | PSILOCIN | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL119584 | — | EC50 | > | 10000.0 | nM | - |