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Assay Detail

CHEMBL617115

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for its ability to activate phospholipase c by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL322)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE.
J Med Chem (2003) 46 : 3526 -3535
PubMed 12877591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.58 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL26687 MESCALINE 1.0 1 5.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL26687 MESCALINE EC50 = 2600.0 nM 5.58