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Assay Detail

CHEMBL617264

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat tissue homogenate
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Tissue
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL322)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Campiani G, Butini S, Gemma S, Nacci V, Fattorusso C, Catalanotti B, Giorgi G, Cagnotto A, Goegan M, Mennini T, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, Galletti B, Stasi MA, Castorina M, Pacifici L, Ghirardi O, Tinti O, Carminati P.
J Med Chem (2002) 45 : 344 -359
PubMed 11784139 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.29 8.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332600 1 8.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332600 Ki = 5.129 nM 8.29