Assay Detail
Binding
CHEMBL617266
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant for in vitro inhibition of [3H]ketanserin binding to rat frontal cortex membranes 5-hydroxytryptamine 2A receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Butyrophenone analogues: Synthesis of 2-methyl-3-ethyl-5-aminoethyl-4,5,6,7-tetrahydroindol-4-ones, and their affinities for d1, d2 and 5-ht2a receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.66 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.70 |
| CHEMBL155006 | — | — | 1 | 7.04 |
| CHEMBL349997 | — | — | 1 | 6.04 |
| CHEMBL460 | MOLINDONE | 4.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL155006 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL349997 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL460 | MOLINDONE | Ki | = | 1412.54 | nM | 5.85 |