Assay Detail
Binding
CHEMBL617267
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Inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor rat frontal cortex membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.26 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 8.84 |
| CHEMBL87717 | — | — | 1 | 8.60 |
| CHEMBL87458 | — | — | 1 | 8.42 |
| CHEMBL87943 | — | — | 1 | 8.11 |
| CHEMBL87026 | — | — | 1 | 7.89 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1065 | METHYSERGIDE | Ki | = | 1.445 | nM | 8.84 |
| CHEMBL87717 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL87458 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL87943 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL87026 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 19.95 | nM | 7.70 |