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Assay Detail

CHEMBL617331

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested for the binding affinity against 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL322)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Campiani G, Morelli E, Gemma S, Nacci V, Butini S, Hamon M, Novellino E, Greco G, Cagnotto A, Goegan M, Cervo L, Dalla Valle F, Fracasso C, Caccia S, Mennini T.
J Med Chem (1999) 42 : 4362 -4379
PubMed 10543880 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.10 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL137621 1 6.10
CHEMBL423899 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL137621 Ki = 794.33 nM 6.10
CHEMBL423899 Ki < 10000.0 nM -