Assay Detail
Binding
CHEMBL617460
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Binding affinity towards 5-hydroxytryptamine 2A receptor binding site using [3H]ketanserin.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.72 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279586 | — | — | 1 | 7.85 |
| CHEMBL59335 | — | — | 1 | 7.60 |
| CHEMBL64344 | — | — | 1 | 7.57 |
| CHEMBL60267 | — | — | 1 | 7.47 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.26 |
| CHEMBL42228 | — | — | 1 | 7.18 |
| CHEMBL61747 | — | — | 1 | 7.08 |
| CHEMBL59940 | — | — | 1 | 6.82 |
| CHEMBL416506 | — | — | 1 | 6.60 |
| CHEMBL61539 | — | — | 1 | 6.57 |
| CHEMBL59464 | — | — | 1 | 6.44 |
| CHEMBL60859 | BMY-14802 | — | 1 | 6.08 |
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 5.70 |
| CHEMBL62994 | — | — | 1 | 5.43 |
| CHEMBL303336 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279586 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL59335 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL64344 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL60267 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL42228 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL61747 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL59940 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL416506 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL61539 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL59464 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL61479 | SIRAMESINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL62994 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL303336 | — | IC50 | = | 7100.0 | nM | 5.15 |