Assay Detail
Binding
CHEMBL617465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity using [3H]MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.12 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131745 | — | — | 1 | 6.68 |
| CHEMBL65547 | PSILOCIN | 2.0 | 1 | 6.41 |
| CHEMBL137485 | — | — | 1 | 6.40 |
| CHEMBL336126 | — | — | 1 | 6.36 |
| CHEMBL132592 | — | — | 1 | 5.89 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 5.80 |
| CHEMBL336800 | — | — | 1 | 5.33 |
| CHEMBL133939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131745 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL65547 | PSILOCIN | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL137485 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL336126 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL132592 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL336800 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL133939 | — | Ki | > | 9400.0 | nM | - |