Assay Detail
Binding
CHEMBL617469
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Ability to displace [3H]ketanserin bound to 5-hydroxytryptamine 2A receptor in rat pre-frontal cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.51 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352107 | — | — | 1 | 5.58 |
| CHEMBL43355 | — | — | 1 | 5.52 |
| CHEMBL287987 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352107 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL43355 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL287987 | — | Ki | = | 3700.0 | nM | 5.43 |