Assay Detail
Binding
CHEMBL617472
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Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor in NIH3T3 cell line membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539057 | — | — | 1 | 8.52 |
| CHEMBL90882 | — | — | 1 | 8.52 |
| CHEMBL89970 | — | — | 1 | 8.40 |
| CHEMBL556969 | — | — | 1 | 8.22 |
| CHEMBL163863 | — | — | 1 | 8.22 |
| CHEMBL544418 | — | — | 1 | 7.66 |
| CHEMBL432762 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539057 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL90882 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL89970 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL556969 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL163863 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL544418 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL432762 | — | Ki | = | 47.0 | nM | 7.33 |