Assay Detail
Binding
CHEMBL617473
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Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.67 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.80 |
| CHEMBL542029 | — | — | 1 | 8.35 |
| CHEMBL554670 | — | — | 1 | 8.22 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.10 |
| CHEMBL555362 | — | — | 1 | 7.70 |
| CHEMBL544184 | — | — | 1 | 7.14 |
| CHEMBL163239 | — | — | 1 | 6.12 |
| CHEMBL94067 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL542029 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL554670 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL42 | CLOZAPINE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL555362 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL544184 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL163239 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL94067 | — | Ki | = | 1200.0 | nM | 5.92 |