Assay Detail
Binding
CHEMBL617476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity at [3H]ketanserin-labeled 5-hydroxytryptamine 2A receptor in rat brain homogenate was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.50 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305275 | — | — | 1 | 7.75 |
| CHEMBL69700 | — | — | 1 | 7.66 |
| CHEMBL304498 | — | — | 1 | 6.19 |
| CHEMBL66241 | — | — | 1 | 6.01 |
| CHEMBL445106 | — | — | 1 | 5.98 |
| CHEMBL307770 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305275 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL69700 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL304498 | — | Ki | = | 644.0 | nM | 6.19 |
| CHEMBL66241 | — | Ki | = | 967.0 | nM | 6.01 |
| CHEMBL445106 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL307770 | — | Ki | = | 3880.0 | nM | 5.41 |