Assay Detail
Binding
CHEMBL617477
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Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2A receptor
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.10 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7430 | — | — | 1 | 8.52 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 8.15 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.10 |
| CHEMBL327713 | — | — | 1 | 7.52 |
| CHEMBL73538 | — | — | 1 | 7.41 |
| CHEMBL91350 | — | — | 1 | 7.14 |
| CHEMBL90654 | — | — | 1 | 7.13 |
| CHEMBL266723 | — | — | 1 | 6.85 |
| CHEMBL89719 | — | — | 1 | 6.70 |
| CHEMBL94067 | — | — | 3 | 6.08 |
| CHEMBL269396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7430 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL42 | CLOZAPINE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL327713 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL73538 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL91350 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL90654 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL266723 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL89719 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL94067 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL94067 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL94067 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL269396 | — | Ki | > | 1000.0 | nM | - |