Assay Detail
Binding
CHEMBL617478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.83 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7617 | — | — | 1 | 8.70 |
| CHEMBL90882 | — | — | 1 | 8.52 |
| CHEMBL88464 | — | — | 1 | 8.52 |
| CHEMBL275696 | — | — | 1 | 8.52 |
| CHEMBL89970 | — | — | 1 | 8.40 |
| CHEMBL91310 | — | — | 1 | 7.96 |
| CHEMBL7828 | ISOLOXAPINE | — | 1 | 7.96 |
| CHEMBL432762 | — | — | 1 | 7.33 |
| CHEMBL90977 | — | — | 1 | 7.01 |
| CHEMBL328246 | — | — | 1 | 6.64 |
| CHEMBL88870 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7617 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL90882 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL88464 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL275696 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL89970 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL91310 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL7828 | ISOLOXAPINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL432762 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL90977 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL328246 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL88870 | — | Ki | = | 250.0 | nM | 6.60 |