Assay Detail
Binding
CHEMBL617483
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Binding affinity against 5-hydroxytryptamine 2A receptor from rat forebrain using [3H]ketanserin as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.84 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 8.80 |
| CHEMBL152408 | PIMETHIXENE | 2.0 | 1 | 8.60 |
| CHEMBL152407 | — | — | 1 | 8.40 |
| CHEMBL152622 | — | — | 1 | 8.05 |
| CHEMBL347536 | — | — | 1 | 7.89 |
| CHEMBL348199 | — | — | 1 | 6.70 |
| CHEMBL152289 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL152408 | PIMETHIXENE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL152407 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL152622 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL347536 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL348199 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL152289 | — | Ki | = | 355.0 | nM | 6.45 |