Assay Detail
Binding
CHEMBL617559
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Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.24 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27403 | — | — | 1 | 6.91 |
| CHEMBL51118 | — | — | 1 | 6.33 |
| CHEMBL301765 | — | — | 1 | 6.22 |
| CHEMBL54914 | — | — | 1 | 6.02 |
| CHEMBL299231 | — | — | 1 | 6.02 |
| CHEMBL53490 | — | — | 1 | 5.77 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.43 |
| CHEMBL299097 | — | — | 1 | 5.24 |
| CHEMBL52612 | — | — | 1 | 4.96 |
| CHEMBL54720 | — | — | 1 | 4.85 |
| CHEMBL53416 | — | — | 1 | 4.62 |
| CHEMBL53573 | — | — | 1 | 4.53 |
| CHEMBL52867 | — | — | 1 | 4.40 |
| CHEMBL416662 | — | — | 1 | 4.33 |
| CHEMBL52625 | — | — | 1 | 4.08 |
| CHEMBL299524 | — | — | 1 | 4.07 |
| CHEMBL300725 | — | — | 1 | - |
| CHEMBL298649 | — | — | 1 | - |
| CHEMBL52772 | — | — | 1 | - |
| CHEMBL53195 | — | — | 1 | - |
| CHEMBL415933 | — | — | 1 | - |
| CHEMBL53662 | — | — | 1 | - |
| CHEMBL50456 | — | — | 1 | - |
| CHEMBL51225 | — | — | 1 | - |
| CHEMBL432897 | — | — | 1 | - |
| CHEMBL50740 | — | — | 1 | - |
| CHEMBL49932 | — | — | 1 | - |
| CHEMBL52007 | — | — | 1 | - |
| CHEMBL299634 | — | — | 1 | - |
| CHEMBL52800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27403 | — | IC50 | = | 123.03 | nM | 6.91 |
| CHEMBL51118 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL301765 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL54914 | — | IC50 | = | 954.99 | nM | 6.02 |
| CHEMBL299231 | — | IC50 | = | 954.99 | nM | 6.02 |
| CHEMBL53490 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL18772 | QUIPAZINE | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL299097 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL52612 | — | IC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL54720 | — | IC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL53416 | — | IC50 | = | 23988.33 | nM | 4.62 |
| CHEMBL53573 | — | IC50 | = | 29512.09 | nM | 4.53 |
| CHEMBL52867 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL416662 | — | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL52625 | — | IC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL299524 | — | IC50 | = | 85113.8 | nM | 4.07 |
| CHEMBL54246 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300692 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL51675 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL410531 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL54125 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52800 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL299634 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL49932 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL50740 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL432897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL51225 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL50456 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53662 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL415933 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52772 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300725 | — | IC50 | > | 100000.0 | nM | - |