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Compound Detail

CHEMBL299097

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C=CCN1CCN(c2nc3ccc4ncccc4c3n3cccc23)CC1

Basic Information

ChEMBL ID CHEMBL299097
Phase Preclinical
Structure Type MOL
InChI Key ILDJOTZORZWBSP-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

343.4
MW (Da)
3.34
ALogP
5
HBA
0
HBD
36.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21N5
MW 343.43
Aromatic Rings 4
Heavy Atoms 26
NP-Likeness -1.33

Activity Summary

IC50 6 meas. best 7.71

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serotonin 3 (5-HT3) receptor
CHEMBL2094132
IC50 7.71 7.71 19.5 1
5-hydroxytryptamine receptor 1A
CHEMBL214
IC50 5.34 5.34 4570.9 1
5-hydroxytryptamine receptor 1D
CHEMBL4105
IC50 5.24 5.24 5754.4 1
5-hydroxytryptamine receptor 1B
CHEMBL3459
IC50 4.71 4.71 19498.5 1
5-hydroxytryptamine receptor 2A
CHEMBL3446
IC50 4.67 4.67 21379.6 1
5-hydroxytryptamine receptor 2C
CHEMBL225
IC50 4.44 4.44 36307.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9191957 10.1021/jm960501o 5-hydroxytryptamine receptor 1A 1
9191957 10.1021/jm960501o 5-hydroxytryptamine receptor 1B 1
9191957 10.1021/jm960501o 5-hydroxytryptamine receptor 1D 1
9191957 10.1021/jm960501o 5-hydroxytryptamine receptor 2A 1
9191957 10.1021/jm960501o 5-hydroxytryptamine receptor 2C 1
9191957 10.1021/jm960501o Serotonin 3 (5-HT3) receptor 1

Data from ChEMBL 36 via Core Engine