Assay Detail
Binding
CHEMBL617604
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Compound was tested for the inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of modifications of the alkylpiperazine moiety of trazodone on 5HT2A and alpha1 receptor binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.37 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL621 | TRAZODONE | 4.0 | 1 | 7.77 |
| CHEMBL117507 | — | — | 1 | 7.77 |
| CHEMBL323688 | — | — | 1 | 7.51 |
| CHEMBL325489 | — | — | 1 | 7.03 |
| CHEMBL118691 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL621 | TRAZODONE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL117507 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL323688 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL325489 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL118691 | — | IC50 | = | 169.0 | nM | 6.77 |