Assay Detail
Binding
CHEMBL617619
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Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Stomach |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.96 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148346 | — | — | 1 | 8.90 |
| CHEMBL297784 | — | — | 1 | 8.50 |
| CHEMBL148347 | — | — | 1 | 8.20 |
| CHEMBL147820 | — | — | 1 | 8.20 |
| CHEMBL2112859 | — | — | 1 | 8.10 |
| CHEMBL148385 | — | — | 1 | 8.00 |
| CHEMBL343666 | — | — | 1 | 8.00 |
| CHEMBL144567 | — | — | 1 | 7.90 |
| CHEMBL315223 | — | — | 1 | 7.80 |
| CHEMBL343455 | — | — | 1 | 7.70 |
| CHEMBL357870 | — | — | 1 | 7.50 |
| CHEMBL356146 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148346 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL297784 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL148347 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL147820 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL2112859 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL148385 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL343666 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL144567 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL315223 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL343455 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL357870 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL356146 | — | Kd | = | 199.53 | nM | 6.70 |