Compound Detail
CHEMBL357870
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Basic Information
| ChEMBL ID | CHEMBL357870 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AZMQHXVJUIAXHL-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
278.3
MW (Da)
3.16
ALogP
2
HBA
2
HBD
61.0
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.9
Kd 1 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B CHEMBL323 | Kd | 7.5 | 7.5 | 31.6 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL324 | Ki | 6.9 | 6.9 | 125.9 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | Kd | = | 31.62 | nM | 7.5 | Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus | 8960557 |
| 5-hydroxytryptamine receptor 2C | Ki | = | 125.89 | nM | 6.9 | Displacement of [3H]mesulergine from rat 5-HT2C receptor expressed in HEK293 | 8960557 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 1584.89 | nM | 5.8 | Displacement of [3H]ketanserin from 5-HT2A receptor of rat frontal cortex | 8960557 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8960557 | 10.1021/jm960571v | 5-hydroxytryptamine receptor 2A | 1 |
| 8960557 | 10.1021/jm960571v | 5-hydroxytryptamine receptor 2B | 1 |
| 8960557 | 10.1021/jm960571v | 5-hydroxytryptamine receptor 2C | 1 |
| 8960557 | 10.1021/jm960571v | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) | 1 |
Data from ChEMBL 36 via Core Engine