Assay Detail
Binding
CHEMBL617257
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Displacement of [3H]ketanserin from 5-HT2A receptor of rat frontal cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.78 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343666 | — | — | 1 | 6.60 |
| CHEMBL148346 | — | — | 1 | 6.40 |
| CHEMBL297784 | — | — | 1 | 6.30 |
| CHEMBL148385 | — | — | 1 | 5.90 |
| CHEMBL357870 | — | — | 1 | 5.80 |
| CHEMBL315223 | — | — | 1 | 5.70 |
| CHEMBL147368 | — | — | 1 | 5.50 |
| CHEMBL148347 | — | — | 1 | 5.50 |
| CHEMBL2112859 | — | — | 1 | 5.50 |
| CHEMBL343455 | — | — | 1 | 5.50 |
| CHEMBL147820 | — | — | 1 | 5.40 |
| CHEMBL144567 | — | — | 1 | 5.30 |
| CHEMBL356146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343666 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL148346 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL297784 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL148385 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL357870 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL315223 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL147368 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL148347 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL2112859 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL343455 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL147820 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL144567 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL356146 | — | Ki | < | 6309.57 | nM | - |