Assay Detail
Functional
CHEMBL617628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus
40
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 39 | 6.62 | 7.50 |
| pA2 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95098 | — | — | 1 | 7.50 |
| CHEMBL87026 | — | — | 1 | 7.40 |
| CHEMBL120903 | — | — | 1 | 7.22 |
| CHEMBL308480 | — | — | 1 | 7.20 |
| CHEMBL110847 | — | — | 1 | 7.19 |
| CHEMBL87943 | — | — | 1 | 7.15 |
| CHEMBL92145 | — | — | 1 | 7.13 |
| CHEMBL159969 | — | — | 1 | 7.06 |
| CHEMBL444269 | — | — | 1 | 7.04 |
| CHEMBL163180 | — | — | 1 | 7.01 |
| CHEMBL349832 | — | — | 1 | 6.90 |
| CHEMBL111393 | — | — | 1 | 6.88 |
| CHEMBL121744 | — | — | 1 | 6.80 |
| CHEMBL111189 | — | — | 1 | 6.80 |
| CHEMBL96781 | — | — | 1 | 6.80 |
| CHEMBL109528 | — | — | 1 | 6.78 |
| CHEMBL143022 | — | — | 1 | 6.71 |
| CHEMBL160019 | — | — | 1 | 6.68 |
| CHEMBL109548 | — | — | 1 | 6.66 |
| CHEMBL159929 | — | — | 1 | 6.63 |
| CHEMBL143027 | — | — | 1 | 6.61 |
| CHEMBL87717 | — | — | 1 | 6.43 |
| CHEMBL142668 | — | — | 1 | 6.36 |
| CHEMBL159771 | — | — | 1 | 6.35 |
| CHEMBL333174 | — | — | 1 | 6.35 |
| CHEMBL109673 | — | — | 1 | 6.35 |
| CHEMBL164471 | — | — | 1 | 6.30 |
| CHEMBL320572 | — | — | 1 | 6.24 |
| CHEMBL110948 | — | — | 1 | 6.23 |
| CHEMBL142316 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95098 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL87026 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL120903 | — | Kd | = | 60.26 | nM | 7.22 |
| CHEMBL308480 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL110847 | — | Kd | = | 64.57 | nM | 7.19 |
| CHEMBL87943 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL92145 | — | Kd | = | 74.13 | nM | 7.13 |
| CHEMBL159969 | — | Kd | = | 87.1 | nM | 7.06 |
| CHEMBL444269 | — | Kd | = | 91.2 | nM | 7.04 |
| CHEMBL163180 | — | Kd | = | 97.72 | nM | 7.01 |
| CHEMBL349832 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL111393 | — | Kd | = | 131.83 | nM | 6.88 |
| CHEMBL121744 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL111189 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL96781 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL109528 | — | Kd | = | 165.96 | nM | 6.78 |
| CHEMBL143022 | — | Kd | = | 194.98 | nM | 6.71 |
| CHEMBL160019 | — | Kd | = | 208.93 | nM | 6.68 |
| CHEMBL109548 | — | Kd | = | 218.78 | nM | 6.66 |
| CHEMBL159929 | — | Kd | = | 234.42 | nM | 6.63 |
| CHEMBL143027 | — | Kd | = | 245.47 | nM | 6.61 |
| CHEMBL87717 | — | Kd | = | 371.54 | nM | 6.43 |
| CHEMBL142668 | — | Kd | = | 436.52 | nM | 6.36 |
| CHEMBL159771 | — | Kd | = | 446.68 | nM | 6.35 |
| CHEMBL333174 | — | Kd | = | 446.68 | nM | 6.35 |
| CHEMBL109673 | — | Kd | = | 446.68 | nM | 6.35 |
| CHEMBL164471 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL320572 | — | Kd | = | 575.44 | nM | 6.24 |
| CHEMBL110948 | — | Kd | = | 588.84 | nM | 6.23 |
| CHEMBL142316 | — | Kd | = | 588.84 | nM | 6.23 |
| CHEMBL87458 | — | Kd | = | 758.58 | nM | 6.12 |
| CHEMBL325253 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL159466 | — | Kd | = | 6606.93 | nM | 5.18 |
| CHEMBL160907 | — | Kd | = | 7244.36 | nM | 5.14 |
| CHEMBL310153 | — | pA2 | - | — | - | |
| CHEMBL95112 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL111509 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL310734 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL159917 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL141600 | — | Kd | > | 10000.0 | nM | - |