Compound Detail
CHEMBL160019
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Basic Information
| ChEMBL ID | CHEMBL160019 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ISMVUGWKBNSWMT-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
3.25
ALogP
5
HBA
0
HBD
45.9
PSA (Ų)
0.82
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 6.68
Ki 2 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 6.72 | 6.72 | 190.6 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL323 | Kd | 6.68 | 6.68 | 208.9 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Kd | 6.3 | 6.3 | 501.2 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.24 | 6.24 | 575.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Ki | = | 190.55 | nM | 6.72 | Inhibitory constant on 5-hydroxytryptamine 2A receptor of Rat frontal cortex | 11754579 |
| 5-hydroxytryptamine receptor 2B | Kd | = | 208.93 | nM | 6.68 | Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2... | 11754579 |
| 5-hydroxytryptamine receptor 2A | Kd | = | 501.19 | nM | 6.3 | Negative log concentration of antagonist on 5-hydroxytryptamine 2A receptor in r... | 11754579 |
| 5-hydroxytryptamine receptor 2C | Ki | = | 575.44 | nM | 6.24 | Inhibitory constant was determined on 5-hydroxytryptamine 2C receptor of Bovine ... | 11754579 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11754579 | 10.1021/jm011014y | 5-hydroxytryptamine receptor 2A | 2 |
| 11754579 | 10.1021/jm011014y | 5-hydroxytryptamine receptor 2B | 1 |
| 11754579 | 10.1021/jm011014y | 5-hydroxytryptamine receptor 2C | 1 |
| 11754579 | 10.1021/jm011014y | Serotonin receptor 2a and 2b (5HT2A and 5HT2B) | 1 |
| 11754579 | 10.1021/jm011014y | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) | 1 |
Data from ChEMBL 36 via Core Engine