Assay Detail
Functional
CHEMBL617951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative log concentration of antagonist on 5-hydroxytryptamine 2A receptor in rat thoracic aorta
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Thoracic aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 37 | 7.62 | 9.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110948 | — | — | 1 | 9.87 |
| CHEMBL333174 | — | — | 1 | 9.50 |
| CHEMBL164471 | — | — | 1 | 9.25 |
| CHEMBL120903 | — | — | 1 | 9.20 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 9.16 |
| CHEMBL320572 | — | — | 1 | 9.13 |
| CHEMBL109673 | — | — | 1 | 9.02 |
| CHEMBL159969 | — | — | 1 | 8.92 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.87 |
| CHEMBL109548 | — | — | 1 | 8.13 |
| CHEMBL87458 | — | — | 1 | 8.12 |
| CHEMBL87717 | — | — | 1 | 8.12 |
| CHEMBL143027 | — | — | 1 | 7.95 |
| CHEMBL308480 | — | — | 1 | 7.86 |
| CHEMBL111393 | — | — | 1 | 7.82 |
| CHEMBL325253 | — | — | 1 | 7.79 |
| CHEMBL95112 | — | — | 1 | 7.63 |
| CHEMBL159929 | — | — | 1 | 7.58 |
| CHEMBL87943 | — | — | 1 | 7.47 |
| CHEMBL96781 | — | — | 1 | 7.35 |
| CHEMBL95098 | — | — | 1 | 7.30 |
| CHEMBL143022 | — | — | 1 | 7.28 |
| CHEMBL310734 | — | — | 1 | 7.27 |
| CHEMBL111509 | — | — | 1 | 7.20 |
| CHEMBL110847 | — | — | 1 | 6.95 |
| CHEMBL111189 | — | — | 1 | 6.83 |
| CHEMBL161423 | — | — | 1 | 6.80 |
| CHEMBL87026 | — | — | 1 | 6.75 |
| CHEMBL92145 | — | — | 1 | 6.72 |
| CHEMBL121744 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110948 | — | Kd | = | 0.1349 | nM | 9.87 |
| CHEMBL333174 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL164471 | — | Kd | = | 0.5623 | nM | 9.25 |
| CHEMBL120903 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL42 | CLOZAPINE | Kd | = | 0.6918 | nM | 9.16 |
| CHEMBL320572 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL109673 | — | Kd | = | 0.955 | nM | 9.02 |
| CHEMBL159969 | — | Kd | = | 1.202 | nM | 8.92 |
| CHEMBL51 | KETANSERIN | Kd | = | 1.349 | nM | 8.87 |
| CHEMBL109548 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL87458 | — | Kd | = | 7.586 | nM | 8.12 |
| CHEMBL87717 | — | Kd | = | 7.586 | nM | 8.12 |
| CHEMBL143027 | — | Kd | = | 11.22 | nM | 7.95 |
| CHEMBL308480 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL111393 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL325253 | — | Kd | = | 16.22 | nM | 7.79 |
| CHEMBL95112 | — | Kd | = | 23.44 | nM | 7.63 |
| CHEMBL159929 | — | Kd | = | 26.3 | nM | 7.58 |
| CHEMBL87943 | — | Kd | = | 33.88 | nM | 7.47 |
| CHEMBL96781 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL95098 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL143022 | — | Kd | = | 52.48 | nM | 7.28 |
| CHEMBL310734 | — | Kd | = | 53.7 | nM | 7.27 |
| CHEMBL111509 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL110847 | — | Kd | = | 112.2 | nM | 6.95 |
| CHEMBL111189 | — | Kd | = | 147.91 | nM | 6.83 |
| CHEMBL161423 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL87026 | — | Kd | = | 177.83 | nM | 6.75 |
| CHEMBL92145 | — | Kd | = | 190.55 | nM | 6.72 |
| CHEMBL121744 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL310153 | — | Kd | = | 331.13 | nM | 6.48 |
| CHEMBL159466 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL163180 | — | Kd | = | 489.78 | nM | 6.31 |
| CHEMBL160019 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL444269 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL159917 | — | Kd | = | 676.08 | nM | 6.17 |
| CHEMBL109528 | — | Kd | = | 1258.93 | nM | 5.90 |