Assay Detail
Binding
CHEMBL617695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity at 5-hydroxytryptamine 2A receptor of the rat brain cortex was assessed on the basis of their ability to displace [3H]ketanserin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Application of similarity matrices and genetic neural networks in quantitative structure-activity relationships of 2- or 4-(4-Methylpiperazino)pyrimidines: 5-HT(2A) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.65 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.80 |
| CHEMBL43163 | — | — | 1 | 8.10 |
| CHEMBL289064 | — | — | 1 | 8.00 |
| CHEMBL43486 | — | — | 1 | 7.30 |
| CHEMBL42261 | — | — | 1 | 6.68 |
| CHEMBL57027 | — | — | 1 | 6.46 |
| CHEMBL56931 | — | — | 1 | 5.57 |
| CHEMBL56116 | — | — | 1 | 5.37 |
| CHEMBL56224 | — | — | 1 | 5.22 |
| CHEMBL56384 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL43163 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL289064 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL43486 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL42261 | — | Ki | = | 208.93 | nM | 6.68 |
| CHEMBL57027 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL56931 | — | Ki | = | 2691.53 | nM | 5.57 |
| CHEMBL56116 | — | Ki | = | 4265.8 | nM | 5.37 |
| CHEMBL56224 | — | Ki | = | 6025.6 | nM | 5.22 |
| CHEMBL56384 | — | Ki | = | 10000.0 | nM | 5.00 |