Assay Detail
Binding
CHEMBL617909
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Evaluated for the binding constant at [125I]-DOI-labeled rat 5-hydroxytryptamine 2A receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.28 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142368 | — | — | 1 | 7.89 |
| CHEMBL143202 | — | — | 1 | 7.60 |
| CHEMBL337590 | — | — | 1 | 7.48 |
| CHEMBL342986 | — | — | 1 | 7.38 |
| CHEMBL142862 | — | — | 1 | 6.91 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | — | 1 | 6.88 |
| CHEMBL444612 | — | — | 1 | 6.84 |
| CHEMBL143031 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142368 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL143202 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL337590 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL342986 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL142862 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL444612 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL143031 | — | Ki | = | 13.0 | — | - |