Assay Detail
Binding
CHEMBL617914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at 5-hydroxytryptamine 2A receptor in rat cortical membrane
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.06 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148752 | — | — | 1 | 7.48 |
| CHEMBL148694 | — | — | 1 | 7.47 |
| CHEMBL148559 | — | — | 1 | 7.47 |
| CHEMBL148353 | — | — | 1 | 7.44 |
| CHEMBL422310 | — | — | 1 | 7.44 |
| CHEMBL358657 | — | — | 1 | 7.32 |
| CHEMBL342536 | — | — | 1 | 7.09 |
| CHEMBL436274 | — | — | 1 | 6.99 |
| CHEMBL356149 | — | — | 1 | 6.91 |
| CHEMBL347959 | — | — | 1 | 6.88 |
| CHEMBL149493 | — | — | 1 | 6.82 |
| CHEMBL146410 | — | — | 1 | 6.60 |
| CHEMBL356171 | — | — | 1 | 6.52 |
| CHEMBL357391 | — | — | 1 | 6.45 |
| CHEMBL355907 | — | — | 1 | - |
| CHEMBL357325 | — | — | 1 | - |
| CHEMBL148965 | — | — | 1 | - |
| CHEMBL146856 | — | — | 1 | - |
| CHEMBL347292 | — | — | 1 | - |
| CHEMBL357743 | — | — | 1 | - |
| CHEMBL148836 | — | — | 1 | - |
| CHEMBL148952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148752 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL148694 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL148559 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL148353 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL422310 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL358657 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL342536 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL436274 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL356149 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL347959 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL149493 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL146410 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL356171 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL357391 | — | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL355907 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357325 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148965 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL146856 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL347292 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357743 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148836 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148952 | — | Ki | > | 1000.0 | nM | - |