Assay Detail
Binding
CHEMBL617916
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In vitro binding affinity at serotonin 5-hydroxytryptamine 2A receptor in rat cortical membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.43 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.17 |
| CHEMBL63576 | — | — | 1 | 7.46 |
| CHEMBL63329 | — | — | 1 | 7.43 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.31 |
| CHEMBL148042 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL63576 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL63329 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL148042 | — | Ki | = | 164.0 | nM | 6.79 |