Assay Detail
Binding
CHEMBL617927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity at 5-hydroxytryptamine 2A receptor was determined using [3H]ketanserin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.50 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111184 | — | — | 1 | 9.26 |
| CHEMBL324270 | — | — | 1 | 9.15 |
| CHEMBL113238 | — | — | 1 | 9.12 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.82 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 8.70 |
| CHEMBL334270 | — | — | 1 | 7.92 |
| CHEMBL109877 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111184 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL324270 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL113238 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL6437 | MIANSERIN | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL334270 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL109877 | — | Ki | = | 277.0 | nM | 6.56 |