Assay Detail
Binding
CHEMBL618066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition 5-lipoxygenase mediated LTB4 formation in rat basophilic leukemia (RBL-1) cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.86 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53532 | — | — | 1 | 6.54 |
| CHEMBL300637 | — | — | 1 | 6.17 |
| CHEMBL301136 | — | — | 1 | 6.16 |
| CHEMBL297733 | — | — | 1 | 6.16 |
| CHEMBL54156 | — | — | 1 | 6.13 |
| CHEMBL298672 | — | — | 1 | 6.11 |
| CHEMBL299794 | — | — | 1 | 6.06 |
| CHEMBL53610 | — | — | 1 | 6.05 |
| CHEMBL50833 | — | — | 1 | 6.00 |
| CHEMBL417022 | — | — | 1 | 5.85 |
| CHEMBL53805 | — | — | 1 | 5.77 |
| CHEMBL301990 | — | — | 1 | 5.52 |
| CHEMBL298776 | — | — | 1 | 4.92 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53532 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL300637 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL301136 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL297733 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL54156 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL298672 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL299794 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL53610 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL50833 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL417022 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL53805 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL301990 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL298776 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 24000.0 | nM | 4.62 |