Assay Detail
Binding
CHEMBL618069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in rat RBL-1 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.24 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275185 | — | — | 1 | 5.75 |
| CHEMBL274642 | BW-755C | — | 1 | 5.70 |
| CHEMBL276767 | — | — | 1 | 5.57 |
| CHEMBL17216 | — | — | 1 | 5.28 |
| CHEMBL8425 | NAFAZATROM | 2.0 | 1 | 5.22 |
| CHEMBL422751 | — | — | 1 | 5.21 |
| CHEMBL16979 | — | — | 1 | 5.14 |
| CHEMBL16962 | — | — | 1 | 5.13 |
| CHEMBL16893 | — | — | 1 | 5.05 |
| CHEMBL17243 | — | — | 1 | 4.95 |
| CHEMBL17067 | — | — | 1 | 4.66 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275185 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL274642 | BW-755C | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL276767 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL17216 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL8425 | NAFAZATROM | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL422751 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL16979 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL16962 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL16893 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL17243 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL17067 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL6 | INDOMETHACIN | IC50 | >> | 20000.0 | nM | - |