Compound Detail
CHEMBL8425
NAFAZATROM 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL8425 |
| Name | NAFAZATROM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ISBUYSPRIJRBKX-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
10
Publications
3
Known Names
Molecular Properties
268.3
MW (Da)
2.83
ALogP
3
HBA
0
HBD
41.9
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 5 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL215 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 5.6 | 5.03 | 2500.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of [14C]arachidonic acid conversion to 5-HETE by broken cell 5-LO iso... | - |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 2500.0 | nM | 5.6 | Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(... | 2213827 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of 5-lipoxygenase in rat RBL-1 cells | 2319562 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 10000.0 | nM | 5.0 | In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay) | 2213827 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 50000.0 | nM | 4.3 | In vitro inhibition of LTB4 production was measured in rat blood | 1848292 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2319562 | 10.1021/jm00166a013 | Unchecked | 5 |
| 1848292 | 10.1021/jm00107a023 | Polyunsaturated fatty acid 5-lipoxygenase | 2 |
| 2213827 | 10.1021/jm00172a010 | Polyunsaturated fatty acid 5-lipoxygenase | 2 |
| 2213827 | 10.1021/jm00172a010 | Mus musculus | 2 |
| 1848292 | 10.1021/jm00107a023 | Cyclooxygenase | 1 |
| - | 10.1016/S0960-894X(00)80655-1 | Oryctolagus cuniculus | 1 |
| - | 10.1016/S0960-894X(00)80655-1 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| 2319562 | 10.1021/jm00166a013 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| 2319562 | 10.1021/jm00166a013 | Prostaglandin G/H synthase 2 | 1 |
| 2213827 | 10.1021/jm00172a010 | Cyclooxygenase | 1 |
Data from ChEMBL 36 via Core Engine