Assay Detail
Binding
CHEMBL619245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.59 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.40 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.30 |
| CHEMBL8562 | — | — | 1 | 6.22 |
| CHEMBL92758 | — | — | 1 | 6.05 |
| CHEMBL93310 | — | — | 1 | 6.00 |
| CHEMBL91981 | — | — | 1 | 6.00 |
| CHEMBL93670 | — | — | 1 | 5.96 |
| CHEMBL93599 | — | — | 1 | 5.70 |
| CHEMBL316996 | — | — | 1 | 5.70 |
| CHEMBL313860 | — | — | 1 | 5.70 |
| CHEMBL274642 | BW-755C | — | 1 | 5.70 |
| CHEMBL8425 | NAFAZATROM | 2.0 | 1 | 5.60 |
| CHEMBL329606 | — | — | 1 | 5.60 |
| CHEMBL93598 | — | — | 1 | 5.46 |
| CHEMBL91004 | — | — | 1 | 5.30 |
| CHEMBL93046 | — | — | 1 | 4.30 |
| CHEMBL91982 | — | — | 1 | 4.30 |
| CHEMBL413482 | — | — | 1 | 4.30 |
| CHEMBL273584 | — | — | 1 | - |
| CHEMBL328432 | — | — | 1 | - |
| CHEMBL94042 | — | — | 1 | - |
| CHEMBL94220 | — | — | 1 | - |
| CHEMBL432054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL8562 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL92758 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL93310 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL91981 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL93670 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL93599 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL316996 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL313860 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL274642 | BW-755C | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL8425 | NAFAZATROM | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL329606 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL93598 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL91004 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL93046 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL91982 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL413482 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL273584 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL328432 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL94042 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL94220 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL432054 | — | IC50 | > | 50000.0 | nM | - |