Assay Detail
Functional
CHEMBL781694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of LTB4 production was measured in rat blood
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.66 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144716 | — | — | 1 | 6.57 |
| CHEMBL1719803 | — | — | 1 | 6.51 |
| CHEMBL1984519 | — | — | 1 | 6.44 |
| CHEMBL3144717 | — | — | 1 | 6.40 |
| CHEMBL3144578 | — | — | 1 | 6.27 |
| CHEMBL3144586 | — | — | 1 | 6.26 |
| CHEMBL3144719 | — | — | 1 | 6.21 |
| CHEMBL3144714 | — | — | 1 | 6.11 |
| CHEMBL3144577 | — | — | 1 | 6.01 |
| CHEMBL3144584 | — | — | 1 | 6.00 |
| CHEMBL3144574 | — | — | 1 | 5.96 |
| CHEMBL3144583 | — | — | 1 | 5.89 |
| CHEMBL3144575 | — | — | 1 | 5.85 |
| CHEMBL3144582 | — | — | 1 | 5.85 |
| CHEMBL3144579 | — | — | 1 | 5.82 |
| CHEMBL3144722 | — | — | 1 | 5.75 |
| CHEMBL3144715 | — | — | 1 | 5.75 |
| CHEMBL276725 | — | — | 1 | 5.70 |
| CHEMBL3144718 | — | — | 1 | 5.62 |
| CHEMBL3144573 | — | — | 1 | 5.60 |
| CHEMBL3144720 | — | — | 1 | 5.58 |
| CHEMBL8747 | REV-5901 | — | 1 | 5.52 |
| CHEMBL3144576 | — | — | 1 | 5.52 |
| CHEMBL412905 | — | — | 1 | 5.52 |
| CHEMBL3144580 | — | — | 1 | 5.51 |
| CHEMBL8612 | — | — | 1 | 5.47 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 5.30 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.00 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.00 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144716 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1719803 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1984519 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3144717 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3144578 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3144586 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3144719 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3144714 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3144577 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3144584 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3144574 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3144583 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3144575 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3144582 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3144579 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3144722 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3144715 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL276725 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3144718 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3144573 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3144720 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3144576 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL412905 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL8747 | REV-5901 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3144580 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL8612 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL50 | QUERCETIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3144581 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL274642 | BW-755C | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL274403 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL8425 | NAFAZATROM | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3144723 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL3144587 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL268241 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL8289 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL276476 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL8099 | — | IC50 | > | 30000.0 | nM | - |