Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL618085

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for rodent 5-hydroxytryptamine 5A receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 5A (CHEMBL3426)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Glennon RA.
J Med Chem (2003) 46 : 2795 -2812
PubMed 12825922 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.92 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL24462 1 8.52
CHEMBL96504 1 7.89
CHEMBL442 ERGOTAMINE 4.0 1 7.40
CHEMBL277120 1 7.40
CHEMBL93240 METITEPINE 2.0 1 7.00
CHEMBL97518 1 6.70
CHEMBL39 SEROTONIN 3.0 1 6.60
CHEMBL13816 1 6.00
CHEMBL56 8-OH-DPAT 1 6.00
CHEMBL278509 1 5.68
CHEMBL263881 LYSERGIDE 2.0 1 -
CHEMBL274384 1 -
CHEMBL433352 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL24462 Ki = 3.0 nM 8.52
CHEMBL96504 Ki = 13.0 nM 7.89
CHEMBL442 ERGOTAMINE Ki = 40.0 nM 7.40
CHEMBL277120 Ki = 40.0 nM 7.40
CHEMBL93240 METITEPINE Ki = 100.0 nM 7.00
CHEMBL97518 Ki = 200.0 nM 6.70
CHEMBL39 SEROTONIN Ki = 250.0 nM 6.60
CHEMBL13816 Ki = 1000.0 nM 6.00
CHEMBL56 8-OH-DPAT Ki = 1000.0 nM 6.00
CHEMBL278509 Ki = 2100.0 nM 5.68
CHEMBL263881 LYSERGIDE Ki < 10.0 nM -
CHEMBL274384 Ki < 10.0 nM -
CHEMBL433352 Ki < 10.0 nM -