Assay Detail
Functional
CHEMBL618339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 8.02 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17002 | — | — | 1 | 8.86 |
| CHEMBL16677 | — | — | 1 | 8.83 |
| CHEMBL16787 | — | — | 1 | 8.82 |
| CHEMBL16866 | — | — | 1 | 8.75 |
| CHEMBL432664 | — | — | 1 | 8.73 |
| CHEMBL273807 | — | — | 1 | 8.71 |
| CHEMBL275605 | — | — | 1 | 8.69 |
| CHEMBL278039 | — | — | 1 | 8.67 |
| CHEMBL277386 | — | — | 1 | 8.67 |
| CHEMBL16929 | — | — | 1 | 8.65 |
| CHEMBL17003 | — | — | 1 | 8.63 |
| CHEMBL275427 | — | — | 1 | 8.61 |
| CHEMBL17341 | — | — | 1 | 8.56 |
| CHEMBL17167 | — | — | 1 | 8.48 |
| CHEMBL17202 | — | — | 1 | 8.44 |
| CHEMBL444281 | — | — | 1 | 8.43 |
| CHEMBL16741 | — | — | 1 | 8.41 |
| CHEMBL16534 | — | — | 1 | 8.31 |
| CHEMBL275606 | — | — | 1 | 8.27 |
| CHEMBL275360 | — | — | 1 | 8.11 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | — | 1 | 8.11 |
| CHEMBL275149 | — | — | 1 | 8.01 |
| CHEMBL27081 | — | — | 1 | 8.01 |
| CHEMBL17141 | — | — | 1 | 7.82 |
| CHEMBL16931 | — | — | 1 | 7.79 |
| CHEMBL27043 | — | — | 1 | 7.79 |
| CHEMBL17294 | — | — | 1 | 7.78 |
| CHEMBL17173 | — | — | 1 | 7.58 |
| CHEMBL17299 | — | — | 1 | 7.47 |
| CHEMBL27041 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17002 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL16677 | — | Ki | = | 1.48 | nM | 8.83 |
| CHEMBL16787 | — | Ki | = | 1.52 | nM | 8.82 |
| CHEMBL16866 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL432664 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL273807 | — | Ki | = | 1.97 | nM | 8.71 |
| CHEMBL275605 | — | Ki | = | 2.04 | nM | 8.69 |
| CHEMBL278039 | — | Ki | = | 2.13 | nM | 8.67 |
| CHEMBL277386 | — | Ki | = | 2.14 | nM | 8.67 |
| CHEMBL16929 | — | Ki | = | 2.22 | nM | 8.65 |
| CHEMBL17003 | — | Ki | = | 2.35 | nM | 8.63 |
| CHEMBL275427 | — | Ki | = | 2.47 | nM | 8.61 |
| CHEMBL17341 | — | Ki | = | 2.74 | nM | 8.56 |
| CHEMBL17167 | — | Ki | = | 3.34 | nM | 8.48 |
| CHEMBL17202 | — | Ki | = | 3.65 | nM | 8.44 |
| CHEMBL444281 | — | Ki | = | 3.71 | nM | 8.43 |
| CHEMBL16741 | — | Ki | = | 3.93 | nM | 8.41 |
| CHEMBL16534 | — | Ki | = | 4.92 | nM | 8.31 |
| CHEMBL275606 | — | Ki | = | 5.42 | nM | 8.27 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | Ki | = | 7.75 | nM | 8.11 |
| CHEMBL275360 | — | Ki | = | 7.75 | nM | 8.11 |
| CHEMBL275149 | — | Ki | = | 9.88 | nM | 8.01 |
| CHEMBL27081 | — | Ki | = | 9.75 | nM | 8.01 |
| CHEMBL17141 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL16931 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL27043 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL17294 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL17173 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL17299 | — | Ki | = | 33.7 | nM | 7.47 |
| CHEMBL27041 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL16984 | — | Ki | = | 43.4 | nM | 7.36 |
| CHEMBL17123 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL16997 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL16724 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL17103 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL16908 | — | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL417812 | — | Ki | = | 1760.0 | nM | 5.75 |