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Compound Detail

CHEMBL16866

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CCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CC)c1=O

Basic Information

ChEMBL ID CHEMBL16866
Phase Preclinical
Structure Type MOL
InChI Key QSLQKBGBPSFDMJ-UHFFFAOYSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

447.5
MW (Da)
2.92
ALogP
7
HBA
2
HBD
111.0
PSA (Ų)
0.45
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H25N5O4
MW 447.50
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness -1.45

Activity Summary

Ki 4 meas. best 8.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2b
CHEMBL255
Ki 8.75 8.75 1.8 1
Adenosine receptor A1
CHEMBL318
Ki 8.03 7.745 9.3 2
Adenosine receptor A2a
CHEMBL302
Ki 7.15 7.15 71.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10737749 10.1021/jm990421v Adenosine receptor A1 1
10737749 10.1021/jm990421v Adenosine receptor A2a 1
10737749 10.1021/jm990421v Adenosine receptor A2b 1
10737749 10.1021/jm990421v Adenosine receptor A3 1
3806597 10.1021/jm00384a037 Adenosine A2 receptor 1
3806597 10.1021/jm00384a037 Adenosine receptor A1 1

Data from ChEMBL 36 via Core Engine