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Compound Detail

CHEMBL16984

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CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(CC(=O)OCC)CC(=O)OCC)cc3)[nH]c2n(CCC)c1=O

Basic Information

ChEMBL ID CHEMBL16984
Phase Preclinical
Structure Type MOL
InChI Key ORPNWGHVSQBASK-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

557.6
MW (Da)
1.71
ALogP
11
HBA
1
HBD
154.8
PSA (Ų)
0.29
QED
2
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H35N5O8
MW 557.60
Aromatic Rings 3
Heavy Atoms 40
NP-Likeness -1.10

Activity Summary

Ki 3 meas. best 7.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 7.57 7.57 26.8 1
Adenosine receptor A2b
CHEMBL255
Ki 7.36 7.36 43.4 1
Adenosine receptor A2a
CHEMBL302
Ki 6.0 6.0 999.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10737749 10.1021/jm990421v Adenosine receptor A1 1
10737749 10.1021/jm990421v Adenosine receptor A2a 1
10737749 10.1021/jm990421v Adenosine receptor A2b 1

Data from ChEMBL 36 via Core Engine