Assay Detail
Functional
CHEMBL618550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against ovarian tumor cell line A2780 after 72 hr continuous exposure to compound
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.33 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 5.00 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 4.30 |
| CHEMBL47665 | — | — | 1 | 4.00 |
| CHEMBL47461 | — | — | 1 | 4.00 |
| CHEMBL45742 | — | — | 1 | - |
| CHEMBL48010 | — | — | 1 | - |
| CHEMBL48076 | — | — | 1 | - |
| CHEMBL298459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL47665 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL47461 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL45742 | — | IC50 | = | 375000.0 | nM | - |
| CHEMBL48010 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL48076 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL298459 | — | IC50 | = | 538000.0 | nM | - |