Assay Detail

CHEMBL618551

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxic effect in ovarian cancer cell line (A2780)

ChEMBL ↗

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Target

A2780 (CHEMBL614004) ↗

Open DB target context

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A2780 (CHEMBL614004) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A2780

CHEMBL614004

Anchored from Assay target.

Protein identity A2780

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A2780
Confidence	1 — Organism
Curated By	Expert

Target

A2780 (CHEMBL614004) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.

Misra RN, Rawlins DB, Xiao HY, Shan W, Bursuker I, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR.
Bioorg Med Chem Lett (2003) 13 : 1133 -1136
PubMed 12643928 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.24	5.24

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL14619	SQ-67563	—	1	5.24

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL14619	SQ-67563	IC50	=	5800.0	nM	5.24