Assay Detail
Functional
CHEMBL618554
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The compound was tested for cytotoxic activity against A2780 cell line(human ovarian carcinoma )
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N4-(omega-Aminoalkyl)-1-[(omega-aminoalkyl)amino]-4- acridinecarboxamides: novel, potent, cytotoxic, and DNA-binding agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.57 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104423 | — | — | 1 | 8.37 |
| CHEMBL145462 | — | — | 1 | 7.82 |
| CHEMBL146276 | — | — | 1 | 7.07 |
| CHEMBL358134 | — | — | 1 | 7.02 |
| CHEMBL145082 | — | — | 1 | 7.00 |
| CHEMBL145428 | — | — | 1 | 6.96 |
| CHEMBL535811 | — | — | 1 | 6.50 |
| CHEMBL342800 | — | — | 1 | 6.38 |
| CHEMBL9940 | — | — | 1 | 6.29 |
| CHEMBL1794954 | — | — | 1 | 5.71 |
| CHEMBL145573 | — | — | 1 | 5.69 |
| CHEMBL144975 | — | — | 1 | 5.64 |
| CHEMBL144470 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104423 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL145462 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL146276 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL358134 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL145082 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL145428 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL535811 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL342800 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL9940 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1794954 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL145573 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL144975 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL144470 | — | IC50 | = | 12000.0 | nM | 4.92 |